Impact Factor ## 5-Year Impact Factor ## Eigenfactor Score #2. VEGF is up-regulated in many tumors and its contribution to tumor angiogenesis is well defined.
A full-length representative protein would consist of an extracellular region,
Focus: Fertility. 17.906 - 2-year Impact Factor (2021) 20.367 - 5-year Impact Factor (2021) 2.682 - Source Normalized Impact per Paper (SNIP) 9.027 - SCImago Journal Rank (SJR) Speed
Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. Nucleic Acids Res.
FGFR family members differ from one another in their ligand affinities and tissue distribution.
EGFR is a cell surface protein that binds to epidermal growth factor, thus inducing receptor dimerization and tyrosine autophosphorylation leading to cell proliferation.
Obstetrics and Gynecology.
a genome) and (2) they are bound by DNA-binding proteins.DNA binding sites are often associated with specialized proteins known as transcription factors, and are thus linked to transcriptional
CUSTOMER SERVICE: Change of address (except Japan): 14700 Citicorp Drive, Bldg. This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. Mutations in this gene have been associated with obesity and mood disorders. This is effected under Palestinian ownership and in accordance with the best European and international standards. This protein is a receptor for members of the epidermal growth factor family. This cytokine is mainly secreted by macrophages.
Mendelian gene identification through mouse embryo viability screening. IL-4 enhances the activation of transcription factor NF-kappa B induced by TNF-alpha or TCR engagement and requires the activation of NF-kappa B to protect cells from apoptosis induced by TCR engagement. The empty string is the special case where the sequence has length zero, so there are no symbols in the string.
The encoded protein plays a role in thymocyte proliferation and is involved in the inflammatory response. Society of Gynecologic Surgeons 48th Annual Scientific Meeting.
MITF (Melanocyte Inducing Transcription Factor) is a Protein Coding gene.
Summary. In mouse strains lacking lacking IL-4 or IL-4 receptor alpha, a mechanism for IgE production exists in vivo that is independent of IL-4. The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily.
HOCOMOCO: towards a complete collection of transcription factor binding models for human and mouse via large-scale ChIP-Seq analysis. transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)|The protein encoded by this gene is a transcription factor that binds the consensus sequence 5'-GCCNNNGGC-3'. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide
This gene is one of several cytokine genes clustered on chromosome 11.
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Diseases associated with MITF include Tietz Albinism-Deafness Syndrome and Melanoma, Cutaneous Malignant 8.Among its related pathways are Regulation of retinoblastoma protein and Transport of the SLBP independent Mature mRNA.Gene Ontology (GO) annotations related to
It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. Formal theory.
TFAP2A (Transcription Factor AP-2 Alpha) is a Protein Coding gene. Like human DCs, mouse cells are divided into plasmacytoid and conventional subclasses.
The protein encoded by this gene can be Top Social Media Articles . The MotifMap system provides comprehensive maps of candidate regulatory elements encoded in the genomes of model species using databases of transcription factor binding motifs, refined genome alignments, and a comparative genomic statistical approach-
TCF12 (Transcription Factor 12) is a Protein Coding gene. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. The protein encoded by this gene is a member of the interleukin 1 cytokine family.
The Society of Gynecologic Oncology (SGO) is the premier medical specialty society for health care professionals trained in the comprehensive management of gynecologic cancers.
The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. EUPOL COPPS (the EU Coordinating Office for Palestinian Police Support), mainly through these two sections, assists the Palestinian Authority in building its institutions, for a future Palestinian state, focused on security and justice sector reforms. The FOXM1 transcription factor exhibits pleiotropic C-terminal transcriptional and N-terminal non-transcriptional functions in various biological processes critical for cellular homeostasis. Multiple cytokine-producing subsets of CD4 + cells are characterized by expression of transcription factors, such as T-bet for antitumor Th1 cells and FoxP3/CD25 for protumor Treg.
In the past year, we added new libraries to Enrichr from the following resources: TG GATES, Allen Brain Atlas 10x scRNA-seq, MSigDB Hallmark, Elsevier Pathway Collection, CCLE Proteomics, HMS LINCS KinomeScan, ProteomicsDB, and virus-host PPIs from P-HIPSTer.In addition, we created original gene set libraries from COVID-19 SARS-CoV-2 CRISPR screens, proteomics, and
This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species.
Multiple cytokine-producing subsets of CD4 + cells are characterized by expression of transcription factors, such as T-bet for antitumor Th1 cells and FoxP3/CD25 for protumor Treg.
This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway.
TAF1 (TATA-Box Binding Protein Associated Factor 1) is a Protein Coding gene.
Top Transcription factor binding sites by QIAGEN in the BDNF gene promoter: NRSF form 1; Genomic Locations for BDNF Gene. Forms the heterodimeric complex core-binding factor (CBF) with CBFB.
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Diseases associated with TCF12 include Craniosynostosis 3 and Hypogonadotropic Hypogonadism 26 With Or Without Anosmia.Among its related pathways are Human Embryonic Stem Cell Pluripotency and Signal Transduction.Gene Ontology (GO) annotations related to this gene include DNA-binding
AP-1 controls a number of cellular processes including differentiation, proliferation, and apoptosis. Home Tools View cart Bulk downloads Database stats Contact us Help Update Log FAQ Links How to cite. DNA binding sites are distinct from other binding sites in that (1) they are part of a DNA sequence (e.g.
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family.
The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters; many of these genes encode proteins involved in response to injury and
Murine dendritic cells (DCs) present antigen to CD4 + and CD8 + T cells. [provided by RefSeq, Aug 2015]
CIS-BP Database: Catalog of Inferred Sequence Binding Preferences. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1.
13 October 2022. The protein encoded by this gene is a member of the STAT protein family. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically
Transcription factor C/EBPbeta is an important regulator in controlling lipid metabolism and in the development of diet-induced obesity, as demonstrated in knockout mice.
Kulakovskiy, I. V. et al.
Human genomes include both protein-coding DNA sequences and various types of DNA The human genome is a complete set of nucleic acid sequences for humans, encoded as DNA within the 23 chromosome pairs in cell nuclei and in a small DNA molecule found within individual mitochondria.These are usually treated separately as the nuclear genome and the mitochondrial genome.
Latest Assembly chr11:27,654,893-27,722,058 (GRCh38/hg38) mouse, rat for BDNF Browse OriGene Inhibitory RNA Products For BDNF; VectorBuilder shRNA knockdown vectors for BDNF (ie. This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. Time to Online Publication . Signalling through this kinase leads to cell differentiation.
An official publication of the American Academy of Allergy, Asthma, and Immunology, The Journal of Allergy and Clinical Immunology brings timely clinical papers, instructive case reports, and detailed examinations of state-of-the-art equipment and techniques to clinical allergists, immunologists, dermatologists, internists, and other physicians concerned with
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Further processing of the beta subunit results in the formation of the M10 peptide, which has Gene ID: 18024, updated on 13-Oct-2022. Activator protein 1 (AP-1) is a transcription factor that regulates gene expression in response to a variety of stimuli, including cytokines, growth factors, stress, and bacterial and viral infections. Induced pluripotent stem cells (also known as iPS cells or iPSCs) are a type of pluripotent stem cell that can be generated directly from a somatic cell.The iPSC technology was pioneered by Shinya Yamanaka's lab in Kyoto, Japan, who showed in 2006 that the introduction of four specific genes (named Myc, Oct3/4, Sox2 and Klf4), collectively known as Yamanaka factors, encoding DNA binding sites are a type of binding site found in DNA where other molecules may bind.
Formally, a string is a finite, ordered sequence of characters such as letters, digits or spaces. The encoded protein functions as either a homodimer or as a heterodimer with similar family members. We show with chromosome conformation capture and gene-expression analysis that the rs17713054-affected enhancer upregulates the interacting gene, leucine zipper transcription factor like 1 (LZTFL1).
This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET.
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Submit a Manuscript . viral and non-viral vectors) In addition to endothelial cells, VEGF and VEGF receptors are expressed on numerous non-endothelial cells including tumor cells.
As a 501(c)(6) organization, the SGO contributes to the advancement of women's cancer care by encouraging research, providing education, raising standards of practice, advocating for patients
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins.
Vascular endothelial growth factor (VEGF) is a potent angiogenic factor and was first described as an essential growth factor for vascular endothelial cells. Supplements.
Murine dendritic cells (DCs) present antigen to CD4 + and CD8 + T cells. This gene encodes a basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a motif that is found in the promoter of the low density lipoprotein receptor gene and other genes involved in sterol biosynthesis.
Like human DCs, mouse cells are divided into plasmacytoid and conventional subclasses. Volume 226, Issue 3, Supplement, S1265-S1370. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation,
The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. Diseases associated with TAF1 include Intellectual Developmental Disorder, X-Linked, Syndromic 33 and Dystonia 3, Torsion, X-Linked.Among its related pathways are RNA Polymerase II Transcription Initiation And Promoter Clearance and Disease.
Welcome to CIS-BP, the online library of transcription factors and their DNA binding motifs.
Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes.
This chemokine is a member of the CC subfamily which is
Ultimately the Diseases associated with TFAP2A include Branchiooculofacial Syndrome and Amblyopia.Among its related pathways are Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors and Apoptosis and Autophagy.Gene Ontology (GO) annotations related to this gene include DNA
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